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Ion Channels of Excitable Membranes
Download PDF Ion Channels of Excitable Membranes
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Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded third edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists.
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Product details
Hardcover: 814 pages
Publisher: Sinauer Associates is an imprint of Oxford University Press; 3 edition (July 16, 2001)
Language: English
ISBN-10: 0878933212
ISBN-13: 978-0878933211
Product Dimensions:
9.6 x 1.3 x 6.9 inches
Shipping Weight: 3.4 pounds (View shipping rates and policies)
Average Customer Review:
4.4 out of 5 stars
20 customer reviews
Amazon Best Sellers Rank:
#906,163 in Books (See Top 100 in Books)
If you're thinking of learning about electrophysiology (not cardiac), this is THE resource. It discusses most of the known ion fluctuations and gives a great deal of background in the proper physics to aid understanding. The style is dry and dense; this is not a book that one reads multiple chapters at a time, but it will be helpful to have on the shelf to look up some information quickly. I took off a star because, as good and highly recommended a resource as this is, it's less practical than other books on electrophysiology. This is a 'before the experiment' book-it helps identify the channels you're looking at, what kind of glass to choose, what drugs might be appropriate for your experiment. It is less helpful with the 'during the experiment' questions than, say, Patch Clamping. It doesn't explain as well what a good seal looks like on your oscilloscope, for instance.To sum: great resource for electrophysiologists, pair with another book for the practical side of actually performing the experiment.
com'mon man. its hille! Absolute necessity for any serious neurophysiologist. Although most people use this as a reference, I read cover to cover. Very readable for someone who has had intro to neuroscience and some Bio background.
If you are interested in the science of electrophysiology, this is your textbook. Starts with basic, ground concepts and works it way up. Begin with an intro of Ohm's law, etc. and the history of electrophysiology and moves to more in depth material for each ion channel. The only drawback is that this is the most up to date version, so there has been some progress since then. But for anyone involved in patch clamping, this is a must read.
The scientist and researcher will find this book of much value as a resource and reference for those studying cellular action, function and response. The book cites many examples of high quality data that are currently pertinent to many avenues of advanced cellular research areas.
This blends mathematical concepts with neurological phenomenon.
I don't think I need to comment on the book itself. It's quite specialized. Those who need it know how good it is.The book I got looks pretty much new. Just as described.
Best book ever
Excellent book about ion channels. I do recommend it to everyone working with those complex systems. 5 stars!Dr. Osvaldo Santos-Filho
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